Vancomycin elution kinetics from porous tantalum metal
نویسندگان
چکیده
منابع مشابه
Porous tantalum and tantalum oxide nanoparticles for regenerative medicine.
For centuries, inflammatory/foreign body reactions have plagued the attempts of clinicians to use metals for tissue and bone reconstructions. Since corrosion contributes to the rejection of metal by the body, an extremely bioinert metal - tantalum - has been successfully used in medicine. The outstanding biocompatibility and flexibility of tantalum established the basis for a growing cadre of c...
متن کاملElution kinetics of vancomycin and gentamicin from carriers and their effects on mesenchymal stem cell proliferation: an in vitro study
BACKGROUND Musculoskeletal infections remain a major complication in orthopedic surgery. The local delivery of antibiotics provides the high levels required to treat an infection without systemic toxicity. However, the local toxicity of antibiotic carriers to the mesenchymal stem cells, as a result of both the peak concentrations and the type of carrier, may be significant. METHODS To address...
متن کاملAntimicrobial properties and elution kinetics of linezolid from polymethylmethacrylate.
Polymethylmethacrylate (PMMA) impregnated with antibiotics is widely used in the treatment of osteomyelitis and infected arthroplasties. With the emergence of resistant bacterial strains, linezolid, which is active against gram-positive bacteria and toward which resistance has been scarce, has been suggested as an alternative. In the current in vitro study, the authors sought to determine and c...
متن کاملBiocompatibility and osteogenic properties of porous tantalum
Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and prolif...
متن کاملPorous tantalum biocomposites for osteochondral defect repair
OBJECTIVES We sought to determine if a durable bilayer implant composed of trabecular metal with autologous periosteum on top would be suitable to reconstitute large osteochondral defects. This design would allow for secure implant fixation, subsequent integration and remodeling. MATERIALS AND METHODS Adult sheep were randomly assigned to one of three groups (n = 8/group): 1. trabecular metal...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research®
سال: 2019
ISSN: 0736-0266
DOI: 10.1002/jor.24160